falciparum erythrocyte membrane protein 1 (PfEMP1) to interact with the B cells. ![]() The infected erythrocytes employ the cysteine-rich interdomain region 1α (CIDR1α) of P. We report here that Plasmodium falciparum-infected erythrocytes directly adhere to and activate peripheral blood B cells from nonimmune donors. Polyclonal B-cell activation and hypergammaglobulinemia are prominent features of human malaria.
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